Castanospermine ≥98%|CAS:79831-76-8|10 mg|50 mg|100 mg

|Castanospermine acts as an inhibitor of N-glycosylation, inhibiting O-GlcNAcase, resulting in immunosuppressive, anti-inflammatory, and antiviral activities. In leukocytes and endothelial cells, castanospermine decreases expression of cellular adhesion molecules ICAM-1, ICAM-2, L-selectin, LFA-1 , VLA-4, Mac-1, and CR4. Castanospermine inhibits metastasis of melanoma cells through a mechanism that involved initial tumor cell arrest. In other cellular models, castanospermine increases secretion of misfolded secretory protein 1 antitrypsin Z. In animal models of arthritis, castanospermine decreases release of inflammatory markers into the synovium, preventing the development of arthritis when given as a pre-treatment and inhibiting disease progression when given after onset. Alteration of glycoprotein processing also inhibits viral replication of the Moloney murine leukemia virus.|C8H15NO4|189.21||+4°C|20 mg/ml HCl