Tacrolimus ≥98%|CAS:104987-11-3|1 mg|5 mg|25 mg

FK-506; Fujimycin; Prograf; Protopic; CCRIS 7124.|Tacrolimus is a calcineurin inhibitor that exhibits immunosuppressive, anti-fibrotic, anti-inflammatory, and anti-allergic activities. Clinically, tacrolimus is used to treat atopic dermatitis and conjunctivitis. In vivo, tacrolimus inhibits synthesis of type I collagen polypeptides and the interaction between LARP6 and FKBP3, suppressing the development of alcohol-induced liver fibrosis. In animal models of OVA-induced allergy, tacrolimus decreases allergic symptoms and levels of IgE, eosinophils, IL-5, and GATA-3.|C44H69NO12|804.02||Ambient|Soluble in DMSO (>3mg/mL), methanol, ethanol, acetone, ethyl acetate, diethyl ether or chloroform.