ENO1 / Enolase 1 / alpha-enolase抗体

ENO1 / Enolase 1 / alpha-enolase抗体产品信息免疫原 :  Recombinant Human ENO1 / Enolase 1 / alpha-enolase protein (Catalog#11554-H07E)
 
Antibody Type :  Rabbit Polyclonal Antibody ( Antibody Purification Platform ) 
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation. 
制备方法 :  Produced in rabbits immunized with purified, recombinant Human ENO1 / Enolase 1 / alpha-enolase (rh ENO1 / Enolase 1 / alpha-enolase; Catalog#11554-H07E; P06733-1; Met1-Lys434). ENO1 / Enolase 1 / alpha-enolase specific IgG was purified by Human ENO1 / Enolase 1 / alpha-enolase affinity chromatography.
ENO1 / Enolase 1 / alpha-enolase抗体 Background
ENO1 (Enolase 1), more commonly known as alpha-enolase (ENOA), is a metabolic enzyme involved in the synthesis of pyruvate. ENO1 also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. The essential role of ENO1 in putative plastid phosphoenolpyruvate (PEP) provision for anabolic processes within plastids, such as the shikimate pathway. The disease-related roles of ENO1 are mostly attributed to its immunogenic capacity, DNA-binding ability and plasmin (ogen) receptor function, which are significantly affected by its three-dimensional structure and surface properties, rather than its enzymatic activity. In tumor cells, ENO1 is upregulated and supports anaerobic proliferation (Warburg effect), it is expressed at the cell surface, where it promotes cancer invasion, and is subjected to a specific array of post-translational modifications, namely acetylation, methylation and phosphorylation. Both ENO1 overexpression and its post-translational modifications could be of diagnostic and prognostic value in cancer.
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