CSNK2A1 / CK2A1抗体产品信息免疫原 : Recombinant Mouse CSNK2A1 / CK2A1 protein (Catalog#50818-M20B)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant Mouse CSNK2A1 / CK2A1 (rM CSNK2A1 / CK2A1; Catalog#50818-M20B; Q60737; Met1-Gln391). CSNK2A1 / CK2A1 specific IgG was purified by Mouse CSNK2A1 / CK2A1 affinity chromatography.
CSNK2A1 / CK2A1抗体 Background
Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser/Thr protein kinase family and CK2 subfamily. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Three transcript variants encoding two different proteins have been found. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains of CSNK2A1 contain the catalytic site. It participates in Wnt signaling. CSNK2A1 is a tetramer composed of an alpha chain, an alpha' and two beta chains. It is also a component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. It interacts with RNPS1 as well.
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