Purine nucleoside phosphorylase / PNP抗体产品信息免疫原 : Recombinant Human Purine nucleoside phosphorylase / PNP protein (Catalog#12097-H08E)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 103
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Human Purine nucleoside phosphorylase / PNP (rh Purine nucleoside phosphorylase / PNP; Catalog#12097-H08E; P00491; Met 1-Ser 289).
Purine nucleoside phosphorylase / PNP抗体 Background
Purine nucleoside phosphorylase, also known as Inosine phosphorylase and PNP, is a cytoplasm protein which belongs to thePNP / MTAP phosphorylase family. Purine nucleoside phosphorylase / PNP is a key enzyme in the purine-salvage pathway, which allows cells to utilize preformed bases and nucleosides in order to synthesize nucleotides. PNP is specific for purine nucleosides in the beta-configuration and exhibits a strong preference for purines containing a 6-keto group and ribosyl-containing nucleosides relative to the corresponding analogues. Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides. PNP is a target for inhibitor development aiming at T-cell immune response modulation and has been submitted to extensive structure-based drug design. Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNP deficiency) which leads to a severe T-cell immuno-deficiency with neurologic disorder in children.
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