ω-CONOTOXIN GVIA / Omega conotoxin GVIA

ω-conotoxin GVIA (omega conotoxin GVIA) has been isolated from the venom of the cone Conus geographus. ω-conotoxin GVIA acts at presynaptic membranes. It binds and blocks specifically voltage-dependent N-type Ca²⁺channels Ca_v2.2 channel with an ED₅₀ of 68pM.

AA sequence: H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂
Hyp: hydroxyproline
(Disulfide bonds between Cys¹-Cys¹⁶, Cys⁸-Cys¹⁹ and Cys¹⁵-Cys²⁶)
Length (aa): 27
Formula: C₁₂₀H₁₈₂N₃₈O₄₃S₆
Molecular Weight: 3036.05 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [106375-28-4]
Source: Synthetic 
Purity rate: > 95 %