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ω-Conotoxin MVIIA / Omega-conotoxin MVIIA

产品信息
  • Smartox Biotechnology是WY一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。


    Catalog N° 08CON001
    ω-Conotoxin MVIIA / Omega-conotoxin MVIIA
    Blocker of N-type voltage-gated calcium channels

    ω-Conotoxin MVIIA (omega-conotoxin MVIIA) has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). ω-conotoxin MVIIA blocks N-type voltage-gated calcium channels (Cav2.2/CACNA1B)ω-conotoxin MVIIA is available as analgesic drug under the name Prialt®. It blocks acute pain in patients who no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium channels and disables nerves that transmit pain signals.

    ω-Conotoxin MVIIA technical information

    AA sequence: Cys1-Lys-Gly-Lys-Gly-Ala-Lys-Cys8-Ser-Arg-Leu-Met-Tyr-Asp-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2
    Disulfide bonds: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25
    Length (aa): 25
    Formula: C102H172N36O32S7
    Molecular Weight: 2639.18 Da

    Appearance: White lyophilized solid
    Solubility: water and saline buffer
    CAS number: [107452-89-1]
    Source: Synthetic 
    Purity rate: > 97 %

    08CON001-00100 ω-Conotoxin MVIIA 0.1mg
    08CON001-00500 ω-Conotoxin MVIIA 0.5mg
    08CON001-01000 ω-Conotoxin MVIIA 1mg
    温馨提示:不可用于临床ZL。
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