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4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers),4-Hydroxy Valproic Acid Sodium Salt,1216888-06-0

产品信息

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    试剂描述：

    产品名称：4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers)

    产品别名：4-Hydroxy-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-4-hydroxypentanoic Acid Sodium Salt

    CAS号：1216888-06-0

    英文别名：4-Hydroxy-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-4-hydroxypentanoic Acid Sodium Salt

    分子量：182.19

    分子式：C8H15O3•Na

    纯度：见爱必信官网

    外观：见爱必信官网

    保存方法：Store at -20° C

    描述：4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) is a racemic mixture of metabolites of Valproic Acid. In the metabolism of Valproic Acid to 4-Hydroxy Valproic Acid, it has been reported that CYP4B1 may play a role in this conversion, as demonstrated using monospecific polyclonal antibodies directed against CYP4B1. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase.

    Metabolites of Valproic Acid are also available as:
    Valproic Acid
    Valproic Acid, Sodium Salt
    3-Hydroxy Valproic Acid
    3-Keto Valproic Acid Sodium Salt
    rac 5-Hydroxy Valproic Acid Sodium Salt
    Valproic Acid β-D-Glucuronide Allyl Ester
    Valproic Acid β-D-Glucuronide

    Labelled forms of Valproic Acid are available as:
    Valproic Acid-d6
    Valproic Acid-d6 β-D-Glucuronide
    rac 5-Hydroxy Valproic Acid-d7 Sodium Salt

    应用：A metabolite of the HDAC inhibitor Valproic acid

    产品信息订购：

      产品货号   产品名称   规格 价格 大包装及货期
      abs42010009   4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers)   100mg  2750   立即咨询

    产品更多信息请进入爱必信网站咨询

    温馨提示：不可用于临床ZL。
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