Anti-TERT/EST2/Telomerase reverse transcriptase端粒酶相关蛋白2抗体（端粒酶逆转录酶）

本公司提供科研TERT/EST2/Telomerase reverse transcriptase端粒酶相关蛋白2抗体（端粒酶逆转录酶），抗体质量可靠，订购TERT/EST2/Telomerase reverse transcriptase端粒酶相关蛋白2抗体（端粒酶逆转录酶）请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：端粒酶相关蛋白2抗体（端粒酶逆转录酶）
英文名称：Anti-TERT/EST2/Telomerase reverse transcriptase
货号：bs-6747R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 126kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.Tissue specificity: Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T lymphocytes, and at a low to undetectable level in peripheral blood T lymphocytes.