Anti-ERK5/SAPK3/MAPK12应激活化蛋白激酶3抗体（丝裂原活化蛋白激酶12）

本公司提供科研ERK5/SAPK3/MAPK12应激活化蛋白激酶3抗体（丝裂原活化蛋白激酶12），抗体质量可靠，订购ERK5/SAPK3/MAPK12应激活化蛋白激酶3抗体（丝裂原活化蛋白激酶12）请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：应激活化蛋白激酶3抗体（丝裂原活化蛋白激酶12）
英文名称：Anti-ERK5/SAPK3/MAPK12
货号：bs-6396R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.Function : Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.Subcellular Location : Cytoplasm. Nucleus. Translocates to the nucleus upon activation.Tissue Specificity : Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.Post-translational modifications : Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain.