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phospho-IRAK4(Thr345)磷酸化白介素-1受体相关激酶4抗体，抗体质量可靠，订购
phospho-IRAK4(Thr345)磷酸化白介素-1受体相关激酶4抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：
磷酸化白介素-1受体相关激酶4抗体英文名称：
Anti-phospho-IRAK4(Thr345)货号：bs-4080R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 51kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, Rb, pig, shp, cow, dog, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Interleukin 1 (IL1) and lipopolysaccharide (LPS) induces cellular responses through IL1 receptor (IL1R) and Toll like receptors (TLR). IL1R associated kinases (IRAK, IRAK2, and IRAKM) regulate the activation of NF-kB and MAP kinase (MAPK) by IL1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK4. Overexpression of IRAK4 activates NF-kB and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1. IRAK4 deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL1R/TLR mediated inflammatory responses and in innate immunity.
