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Paxillin桩蛋白Paxillin抗体，抗体质量可靠，订购
Paxillin桩蛋白Paxillin抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：
桩蛋白Paxillin抗体英文名称：
Anti-Paxillin货号：bs-3539R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 68kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, hrs, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).Function : Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).Subcellular Location : Cytoplasm > cytoskeleton. Cell junction > focal adhesion.Post-translational modifications : Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.Similarity : Belongs to the paxillin family.Contains 4 LIM zinc-binding domains.Paxillin是一种分子量为68KDa的局部粘附蛋白，参与肿瘤细胞的粘附与转移。主要用于各种恶性肿瘤的研究。Paxillin 蛋白是胞外基质细胞粘附（粘着斑）位点上肌动蛋白-膜附着的细胞骨架蛋白。 Paxillin 在整合蛋白的信号传导中起着非常重要的作用，整合蛋白介导的细胞骨架的再组织需要，paxillin 酪氨酸残基的磷酸化。 Paxillin 被粘着斑激酶 (FAK)在其118位的酪氨酸残基处磷酸化。已经证明，paxillin 118位和31位两个酪氨酸的磷酸化对于MM1癌细胞的迁移是重要的。Paxillin在胚胎发育、炎症和多种肿瘤中发挥作用。 产品图片Antigen: bs-3539P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.
