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Phospho-TBK1/NAK (Ser172)磷酸化NF-κB活化激酶抗体，抗体质量可靠，订购
Phospho-TBK1/NAK (Ser172)磷酸化NF-κB活化激酶抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：
磷酸化NF-κB活化激酶抗体英文名称：
Anti-Phospho-TBK1/NAK (Ser172)货号：bs-3440R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 55kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk, hrs, cow, dog, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. Ubiquitous with higher expression in testis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Subunit : Self-associates. Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1.Subcellular Location : Cytoplasm.Tissue Specificity : Ubiquitous with higher expression in testis.Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. Contains 1 protein kinase domain. Contains 1 ubiquitin-like domain.TBK1是NF-κB信号通道中的一种激酶，它是被KRAS-改变的细胞存活所必不可少的。TBK1诱导反凋亡信号，TBK1与NF-κB共同作用于KRAS介导的癌变过程中,可能是一个癌症ZL目标。
