本公司提供科研Phospho-SirT1 (Ser27)磷酸化沉默调节蛋白1抗体，抗体质量可靠，订购Phospho-SirT1 (Ser27)磷酸化沉默调节蛋白1抗体请联系在线客服或者销售人员。 抗体参数如下>>>> 中文名称：磷酸化沉默调节蛋白1抗体 英文名称：Anti-Phospho-SirT1 (Ser27) 货号：bs-3416R 抗体来源：兔 克隆类型：多克隆 蛋白分子量：predicted molecular weight: 82kDa 纯化方法：affinity purified by Protein A 交叉反应：hu, mo, rat 测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 产品背景介绍：This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. Subunit : Found in a complex with PCAF and MYOD1.Subcellular Location : SirtT1 75 kDa fragment: Cytoplasm. Mitochondrion.Tissue Specificity : Widely expressed.Similarity : Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain.在Sirtuin蛋白家族中，sirtuin 1参与多种新陈代谢活动，包括DNA的自我保护和修复，YZ脂质过氧化积累，YZ其他细胞凋亡相关基因的表达以及和细胞寿命相关的活动。限制摄入的热量可以加强SIRT1的表达，从而延长了寿命。
