本公司提供科研
Phospho-PIM1(Tyr218)磷酸化前病毒整合位点蛋白1抗体，抗体质量可靠，订购
Phospho-PIM1(Tyr218)磷酸化前病毒整合位点蛋白1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：
磷酸化前病毒整合位点蛋白1抗体英文名称：
Anti-Phospho-PIM1(Tyr218)货号：bs-3353R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 45kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb, dog, cow, shp
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：PIM1 is a member of the serine/threonine kinase PIM oncogene family. PIM1 has been implicated in lymphomagenesis, cell proliferation, apoptosis, differentiation and tumourigenesis. The PIM1 protein kinase is upregulated in prostate cancer.Subunit : Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Binds to RP9. Isoform 1, but not isoform 2, binds BMX. Isoform 2 interacts with CDKN1B and FOXO3. Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation. Interacts with HSP90, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation. Interacts with CDKN1A. Interacts with CDC25C. Interacts (via N-terminal 96 residues) with CDC2. Interacts with MAP3K5. Interacts with MYC.Subcellular Location : Isoform 2: Cytoplasm. Nucleus. Isoform 1: Cell membrane.Tissue Specificity : Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.Contains 1 protein kinase domain.PIM1蛋白是丝氨酸/苏氨酸蛋白激酶2家族成员，他参与细胞信号转导、细胞凋亡、转录调节，在很多肿瘤中表达，尤其是前列腺癌，表达水平较高。
