本公司提供科研
Rb/P105 RB成视网膜细胞瘤基因抗体，抗体质量可靠，订购
Rb/P105 RB成视网膜细胞瘤基因抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：
成视网膜细胞瘤基因抗体英文名称：
Anti-Rb/P105 RB货号：bs-2777R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 106kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Rb, pig, hrs
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Nuclear MarkerThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
