Anti-Coxsackie Adenovirus Receptor柯萨奇病毒蛋白受体B抗体

本公司提供科研Coxsackie Adenovirus Receptor柯萨奇病毒蛋白受体B抗体，抗体质量可靠，订购Coxsackie Adenovirus Receptor柯萨奇病毒蛋白受体B抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：柯萨奇病毒蛋白受体B抗体
英文名称：Anti-Coxsackie Adenovirus Receptor
货号：bs-2389R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, dog, hrs, cow, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Coxsackie and adenovirus receptor (CAR), also known as CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity. It is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.It is proposed to function as a homophilic cell adhesion molecule and recruits MPDZ to intercellular contact sites. CAR is probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.Subunit : Monomer.Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass membrane protein. Isoform 3, 4, 5: Secreted.Tissue Specificity : Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.Similarity : Contains 2 Ig-like C2-type (immunoglobulin-like) domains.