本公司提供科研RAD51C乳腺癌和卵巢癌易感基因RAD51C抗体，抗体质量可靠，订购RAD51C乳腺癌和卵巢癌易感基因RAD51C抗体请联系在线客服或者销售人员。 抗体参数如下>>>> 中文名称：乳腺癌和卵巢癌易感基因RAD51C抗体 英文名称：Anti-RAD51C 货号：bs-2186R 抗体来源：兔 克隆类型：多克隆 蛋白分子量：predicted molecular weight: 131kDa 纯化方法：affinity purified by Protein A 交叉反应：hu, mo, rat 测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 产品背景介绍：Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.Subcellular Location : Nucleus. Cytoplasm. Tissue Specificity : Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
