本公司提供科研CHN 1/Alpha-chimerinα1-chimaerin蛋白抗体，抗体质量可靠，订购CHN 1/Alpha-chimerinα1-chimaerin蛋白抗体请联系在线客服或者销售人员。 抗体参数如下>>>> 中文名称：α1-chimaerin蛋白抗体 英文名称：Anti-CHN 1/Alpha-chimerin 货号：bs-11539R 抗体来源：兔 克隆类型：多克隆 蛋白分子量：predicted molecular weight: 53kDa 纯化方法：affinity purified by Protein A 交叉反应：hu, mo, rat 测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 产品背景介绍：The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2. The ?-chimaerin variant is a neuron-specific, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1. This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant. By inactivating Rac 1, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development. It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol). Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches. In the presence of reduced neuronal activity, Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching.Function : GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms.Tissue Specificity : In neurons in brain regions that are involved in learning and memory processes.DISEASE : Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.Similarity : Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 Rho-GAP domain.Contains 1 SH2 domain.
