Anti-GNRHR2促性腺素释放激素受体2抗体

本公司提供科研GNRHR2促性腺素释放激素受体2抗体，抗体质量可靠，订购GNRHR2促性腺素释放激素受体2抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：促性腺素释放激素受体2抗体
英文名称：Anti-GNRHR2
货号：bs-11403R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：GnRHR2 is a 379 amino acid multi-pass membrane protein that is expressed in a variety of tissues, where it functions as a G protein coupled receptor for GnRH. Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.Function : Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system Subcellular Location : Cell membrane; Multi-pass membrane protein.