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Prostaglandin I2 Receptor/IP Receptor前列环素受体抗体，抗体质量可靠，订购
Prostaglandin I2 Receptor/IP Receptor前列环素受体抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：
前列环素受体抗体英文名称：
Anti-Prostaglandin I2 Receptor/IP Receptor货号：bs-11307R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：
纯化方法：affinity purified by Protein A
交叉反应：hu, Rb, cow, dog, Monkey, Gorilla
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2?, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main pro-stanoid synthesized by vascular tissues.Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.Function : Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.Subcellular Location : Cell membrane.Post-translational modifications : Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.Similarity : Belongs to the G-protein coupled receptor 1 family.
