Anti-human Fibrinogen Monoclonal人纤维蛋白原单克隆抗体

本公司提供科研human Fibrinogen Monoclonal人纤维蛋白原单克隆抗体，抗体质量可靠，订购human Fibrinogen Monoclonal人纤维蛋白原单克隆抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：人纤维蛋白原单克隆抗体
英文名称：Anti-human Fibrinogen Monoclonal
货号：bsm-1240M
抗体来源：鼠
克隆类型：单克隆
蛋白分子量：predicted molecular weight: 340kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.产品图片Antigen: bs-1240P 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Mouse IgG(bs-0296G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.