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重组鼠类的sRANK配体Recombinant Murine sRANK Ligand,

产品信息
  • 规格： 产品价格： ￥0
    规格： 2µg 产品价格： ￥0
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    Recombinant Murine sRANK Ligand
    产品编号:
    315-11
    别名:
    soluble Receptor Activator of NFkB Ligand,TNFSF11,TRANCE (TNF-related activation-induced cytokine),OPGL,ODF (Osteoclast differentiation factor)
    描述:
    RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant murine sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).
    氨基酸序列:
    PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID
    来源:
    E.coli
    纯度:
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    温馨提示：不可用于临床ZL。
    • 信息声明：本产品供应信息由仪器网为您整合，供应商为（上海瓦兰生物科技有限公司），内容包括 （重组鼠类的sRANK配体Recombinant Murine sRANK Ligand,）的品牌、型号、技术参数、详细介绍等；如果您想了解更多关于 （重组鼠类的sRANK配体Recombinant Murine sRANK Ligand,）的信息，请直接联系供应商，给供应商留言！
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