CD274 Antibody_CD274抗体

CD274 Antibody产品详细介绍：

产品名称：	CD274 Antibody
说明书：	【点击查看详细说明及参考图片】
货号：	251474
规格：	0.1 mg
产品描述：	CD274 is involved in the costimulatory signal transduction cascade which is essential for T-cell proliferation. CD274 is also involved in the production of IL-10 and interferon gamma. Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.
克隆类型：	Rabbit Polyclonal Antibody
亚型：	Rabbit Ig
免疫原：	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD274.
适用物种：	H, M, R
应用范围：	E, WB, IHC
应用说明：	E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
别名：	B7-H1; PDL1; CD274; Programmed death ligand 1; Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; B7 homolog 1; B7H1; PDCD1L1; PDCD1LG1
形态：	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
保存条件：	Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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