| 产品名称： | Sonic Hedgehog Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 251893 |
| 规格： | 0.1 mg |
| 产品描述： | SHH (Sonic hedgehog) is member of the hedgehogy signaling pathway. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Sonic hedgehog is an intercellular signal essential for a variety of patterning events during development, such as ventral cell fate in the neural tube and somites, and for patterning of the anterior-posterior axis of the developing limb bud. Defects in sonic hedgehog has been implicated in eye formation disorders and holoprosencephaly, the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human sonic hedgehog. |
| 适用物种： | H, M, R |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; ICC: 1:100-1:500 |
| 别名： | Sonic hedgehog protein; SHH; HHG-1 |
| 形态： | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2 % BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
