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Caspase-8 (N-term) 1006-1 兔单克隆抗原抗体

产品信息

  • Description

    Caspase-8 (MACH/FLICE/Mch5) is a member of a family of cysteine-requiring aspartate proteases that participate in the intracellular signaling cascade leading to apoptosis, or programmed cell death (1-4). Caspase-8 is recruited to death-inducing signaling complex (DISC) CD95 (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) and is subsequently activated by proteolytic cleavage into two residues, p10 and p18 (1-4). Active caspase-8, the first in the caspase signaling cascade, signals downstream caspases to eventually induce apoptosis.

    Recommended Applications

    WB, IHC, FC, IP
     
    Applications and Recommended Dilution Factors
     
    WB IHC ICC FC IP
    1:500 - 1000 1:100   1:50 1:50

    Species Reactivity*
     
    Human Mouse Rat
    Positive Negative Negative *Cross reactivity determined by western blot only.

     
    Product Data
    A. Western blot analysis on Jurkat cell lysate using anti-Caspase-8 RabMAb (cat. #1006-1), 1:1000 dilution. B. Immunohistochemical analysis of paraffin-embedded human breast adenocarcinoma using anti-Caspase-8 RabMAb (cat. #1006-1).

    Specificity

    A synthetic peptide corresponding to N-terminal residues of human Caspase-8 was used as immunogen. The antibody should recognize all splice isoforms of Caspase-8.

    Storage Buffer & Conditions

    50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

    Alternative Names

    CASP8, MCH5, Caspase-8 subunit p10, Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4

    Description References

    1. Muzio, M. et al. Cell 85: 817-827 (1996)
    2. Boldin, M.P. et al. Cell 85: 803-815 (1996)
    3. Srinivasula, S.M. et al. Proc. Natl. Acad. Sci. U S A 93(25): 14486-91 (1996)
    4. Medema, J.P. et al. EMBO J. 16(10): 2794-804 (1997)
     

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