Rebeccamycin,蝴蝶霉素,93908-02-2

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产品名称：Rebeccamycin

产品别名：蝴蝶霉素

CAS号：93908-02-2

英文别名：rebeccamycin

分子量：570.4

分子式：C₂₇H₂₁Cl₂N₃O₇

纯度：≥98%

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保存方法：Store at -20° C

描述：Rebeccamycin is an indolocarbazole small molecule antibiotic, functional as an inhibitor of Topo I (DNA topoisomerase I). It is suggested that Rebeccamycin and the other related indolocarbazoles intercalate into DNA and prevent topoisomerase activity from a position on the backbone. The stereochemistry of the pendant sugar on Rebeccamycin is demonstrated to be crucial for the specificity of this DNA interaction. The glycosyl moiety is also shown to be essential for the translocation of Rebeccamycin from the lipid membrane into the vital structures of the cell.

应用：An indolocarbazole topoisomerase inhibitor

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