产品名：重组人白介素6 (IL-6)/ Recombinant Human IL-6
产品号：LT0116
产品信息：
白细胞介素-6，简称白介素6 (IL-6)，是一种细胞因子，属于白细胞介素的一种。它是由纤维母细胞、单核/巨噬细胞、T淋巴细胞、B淋巴细胞、上皮细胞、角质细胞、以及多种瘤细胞所产生。IL-1、TNF-α, PDGF、病毒感染、双链RNA及c AMP等，均可诱导正常细胞产生白介素6。白介素6能够刺激参与免疫反应的细胞增殖、分化并提高其功能。
别名:
IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
英文描述:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
表达宿主来源:
E.coli
氨基酸序列:
PVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
保存条件：
4℃保存6个月，-20℃保存一年或-80℃长期保存。
纯度&内毒素
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level<0.5EU//μg
The purity of rhIL6 was determined by SDS-PAGE of reduced rhIL6 and staining overnight with Coomassie Blue.
