| 分子量(MW): | 466.53 | |
|---|---|---|
| 化学式: | C28H26N4O3 | |
| 溶解度: | DMSO ≥93mg/mL Water <1mg/mL Ethanol <1mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 62996-74-1 |
Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The interest in these activities resulted in a large investigative effort in chemistry and biology and the discovery of the potential for anti-cancer treatment. Staurosporine induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons. Staurosporine is a natural product originally isolated from the bacterium Streptomyces staurosporeus. [1][2]
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