现货，R406(free base)，selleck，美国进口，Syk YZ剂，CAS号: 841290-80-0，目录号 S1533

R406 is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM.
R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 was selective as assessed using a large panel of Syk-independent cell-based assays representing both specific and general signaling pathways. Consistent with Syk inhibition, oral administration of R406 to mice reduced immune complex-mediated inflammation in a reverse-passive Arthus reaction and two antibody-induced arthritis models. ^[1][2]

• R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation Sylvia Braselmann, Vanessa Taylor, et al. JPET 2006;319:998–1008
• The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets J.C.SPALTON,J.MORI,et al. J Thromb Haemost 2009;7: 1192–1199

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