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Calpain Inhibitor XII 可逆和选择性钙蛋白酶IYZ剂

产品信息
  • 181769-57-3  Calpain Inhibitor XII 可逆和选择性钙蛋白酶IYZ剂  货号C5347Calpain Inhibitor XII 可逆和选择性钙蛋白酶IYZ剂化学性质
    CAS号 181769-57-3 SDF Download SDF
    别名 Z-L-Nva-CONH-CH2-2-Py
    化学名 [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-carbamic acid, phenylmethyl ester
    SMILES O=C(NC(CC(C)C)C(NC(CCC)C(C(NCC1=NC=CC=C1)=O)=O)=O)OCC2=CC=CC=C2
    分子式 C26H34N4O5 分子量 482.6
    溶解性 Soluble in DMSO 储存条件 Store at -20°C
    运输条件 SY装：蓝冰运输。
    其他可选规格：常温运输或根据您的要求用蓝冰运输。
    一般建议 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。
    Calpain Inhibitor XII 可逆和选择性钙蛋白酶IYZ剂产品描述

    Ki: 19 nM for μ-calpain

    Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I.

    Calpain is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases expressed ubiquitously in mammals and many other organisms. Calpain inhibitors have been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

    In vitro: A series of new dipeptidyl alpha-keto amides of the general structure R1-L-Leu-D,L-AA-CONH-R2 including Calpain Inhibitor XII were synthesized and evaluated as inhibitors for the cysteine proteases calpain I, calpain II, and cathepsin B. Calpain II was more sensitive to these inhibitors Calpain Inhibitor XII than calpain I. Calpain I was also effectively inhibited by Calpain Inhibitor XII, but lower Ki values than with calpain II. Cathepsin B was weakly inhibited by Calpain Inhibitor XII. The best calpain I inhibitor in this study was Calpain Inhibitor XII with Ki value of 19 nM [1].

    In vivo: Up to now, there is no animal in vivo data reported.

    Clinical trial: So far, no clinical study has been conducted.

    Calpain Inhibitor XII 可逆和选择性钙蛋白酶IYZ剂Reference:
    [1] Li, Z. ,Ortega-Vilain, A.C.,Patil, G.S., et al. Novel peptidyl α-keto amide inhibitors of calpains and other cysteine proteases. Journal of Medicinal Chemistry 39(20), 4089-4098 (1996).

    Calpain Inhibitor XII 可逆和选择性钙蛋白酶IYZ剂
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    5. A2602Calpain Inhibitor I, ALLNCalpain I/II/ B/LYZ剂
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    7. C5347Calpain Inhibitor XII可逆和选择性钙蛋白酶IYZ剂
    8. C5830PD 145305钙蛋白酶的选择性YZ剂
    9. A4410Acetyl-Calpastatin (184-210) (human)钙蛋白酶I/IIYZ剂
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    12. A4413PD 150606非肽类钙蛋白酶YZ剂
    13. A4414PMPA (NAALADase inhibitor)NAALADaseYZ剂
    14. A4415ZJ 43GCP II和III/NAAG肽酶/ NAALADaseYZ剂
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    18. C50382-cyano-Pyrimidine组织蛋白酶KYZ剂
    19. A1903E 64d Top Seller半胱氨酸蛋白酶YZ剂
    20. A1926CA 074 Top SellerCathepsin BYZ剂
    21. A8239CA-074 MeCathepsin BYZ剂
    22. A3284Cathepsin S inhibitorYZMHCII抗原呈递
    23. A8174Cathepsin G Inhibitor I Top SellerCathepsin GYZ剂
    24. A2487Odanacatib (MK-0822)组织蛋白酶KYZ剂
    25. A4422L 006235组织蛋白酶KYZ剂
    26. A4424SID 26681509人组织蛋白酶LYZ剂
    27. A4033Glimepiride磺酰脲类化合物
    28. 上海恒斐生物现货供应说明书及YZ剂详情请联系上海恒斐生物021-60493872  刘鑫 17317793691（微信同步）QQ845206284
    温馨提示：不可用于临床ZL。
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