DiscoveryProbe™ Cell Cycle/Checkpoint-related Compounds Panel

Compound Panel Contents

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A2521	VE-821	ATR kinase inhibitor,potent and selective	Cell Cycle/Checkpoint|ATM/ATR	1232410-49-9	CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N
A8807	MK-8745	Aurora A inhibitor,potent and selective	Cell Cycle/Checkpoint|Aurora Kinase	885325-71-3	ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1
A8394	CHIR-124	Chk1 inhibitor,novel and potent	Cell Cycle/Checkpoint|Chk	405168-58-3	C1CN2CCC1C(C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl
B1236	BML-277	Chk2 inhibitor,potent and highly selective	Cell Cycle/Checkpoint|Chk	516480-79-8	C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
A1794	LY2835219	CDK4/6 inhibitor,potent and selective	Cell Cycle/Checkpoint|Cyclin-Dependent Kinases	1231930-82-7	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
A8412	Dinaciclib (SCH727965)	Potent CDK inhibitor	Cell Cycle/Checkpoint|Cyclin-Dependent Kinases	779353-01-4	CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO
A8882	THZ1	Covalent CDK7 inhibitor,potent and selective	Cell Cycle/Checkpoint|Cyclin-Dependent Kinases		ClC1=CN=C(N=C1C2=CNC3=CC=CC=C23)NC4=CC=CC(NC(C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)=O)=C4
A4393	Paclitaxel (Taxol)	Antineoplastic agent	Cell Cycle/Checkpoint|Cytoskeleton	33069-62-4	O=C(N[C@H]([C@H](C(O[C@H]1C[C@]2(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]3(C)[C@]([C@@](CO4)(OC(C)=O)[C@H]4C[C@@H]3O)([H])[C@@H]2OC(C5=CC=CC=C5)=O)=O)=C1C)=O)O)C6=CC=CC=C6)C7=CC=CC=C7
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Advantages

• Available in stock with overnight delivery and free shipping over $500
• Cost-effective and competitive price to save your findings
• Potent, selective and cell-permeable in inhibiting or activating target molecules
• Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
• Detailed files describing potency, selectivity and applications etc.
• Supported by published data from top peer-reviewed journals
• Guaranteed high quality with NMR and HPLC validation

产品描述
A wide range of well-characterized bioactive molecules that covers various targets related to cell cycle/checkpoint, including Chk, CDK and Plk etc. Facilitate your research towards the insights of DNA replication, tumorgenesis and aging etc. Applicable in cellular assays, animal models and drug screenings etc.