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【PTH (1-34)】人甲状旁腺素（1-34）/Human Parathyroid Hormone (1-34)

产品信息
  • Parathyroid hormone （PTH）,or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calciumin the blood， whereas calcitonin （a hormone produced by the parafollicular cells of the thyroid gland） acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH； rather， PTH binds to osteoblasts， the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL， which can bind to osteoclast precursors containing RANK， a receptor for RANKL. The binding of RANKL to RANK stimulates these precursors to fuse， forming new osteoclasts which ultimately enhances the resorption of bone.In the kidney- It enhances active reabsorption of calcium from distal tubules and the thick ascending limb.In the intestine- It enhances the absorption of calcium in the intestine by increasing the production of vitamin D and upregulating the enzyme responsible for 1-alpha hydroxylationof 25-hydroxy vitamin D， converting vitamin D to its active form （1，25-dihydroxy vitamin D） which effects the actual absorption of calcium （as Ca2+ ions） by the intestine via calbindin.Recombinant Human full length PTH 1-84 has potential as an anti-osteoporotic agent， due to its properties as a bone formation stimulant， it increases bone turnover， stimulating osteoblasts and reducing both vertebral and non vertebral fractures.

    序列：The amino acid composition is as followsAla-Val-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe.

    保存建议：Lyophilized Parathyrin although stable at room temperature for 3 weeks should be stored desiccated below -18℃. Upon reconstitution PTH should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
    如需订购：Email:  peptide-4@bankpeptide.com

    电话：17682162835
    温馨提示：不可用于临床ZL。
    • 信息声明：本产品供应信息由仪器网为您整合，供应商为（合肥国肽生物科技有限公司），内容包括 （【PTH (1-34)】人甲状旁腺素（1-34）/Human Parathyroid Hormone (1-34)）的品牌、型号、技术参数、详细介绍等；如果您想了解更多关于 （【PTH (1-34)】人甲状旁腺素（1-34）/Human Parathyroid Hormone (1-34)）的信息，请直接联系供应商，给供应商留言！
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