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财盛生物|bioxcell人种属体内注射PD-L1抗体InVivoMAb anti-human PD-L1 (B7-H1)

产品信息
  • 本产品有1、5、25、50、100mg规格、部分有现货;欢迎咨询!About InVivoMAb anti-human PD-L1 (B7-H1)The 29E.2A3 monoclonal antibody reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. The 29E.2A3 antibody has been shown to block the binding of PD-1-Ig to PD-L1.
     
    Isotype Mouse IgG2b, κ
    Recommended Isotype Control(s) InVivoMAb mouse IgG2b isotype control, unknown specificity(BE0086)
    Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
    Immunogen Full length human PD-L1
    Reported Applications
    • in vitro PD-L1 blockade
    • Functional assays
    • Immunohistochemistry (frozen)
    • Flow cytometry
    Endotoxin
    • <2EU/mg (<0.002EU/μg)
    • Determined by LAL gel clotting assay
    Purity
    • >95%
    • Determined by SDS-PAGE
    Formulation
    • PBS, pH 7.0
    • Contains no stabilizers or preservatives
    Sterility 0.2 μM filtered
    Production Purified from tissue culture supernatant in an animal free facility
    Purification Protein G
    Storage The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.
    RRID AB_2687808

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