CYFRA 21-1 is a fragment of cytokeratin 19. Although expressed in all body tissues its major occurrence is in the lung, particulary in lung cancer tissues. The major diagnostic importance of CYFRA 21-1 as a tumor marker is in differential diagnosis, prognosis, and aftercare of non-small-cell lung cancer (NSCLC) patients.
Additionally, CYFRA 21-1 has been described as a tumor marker for the monitoring of bladder cancer.
The CYFRA 21-1 ELISA Kit uses the two mouse monoclonal antibodies KS19.1 and BM19.21 to determine cytokeratin 19 fragments.
