Synuclein-α, Nitrated Monoclonal Antibody
- 品牌： R&D
- 型号：xy-556R
- 产地： 美国/中国
- 供应商：上海信裕生物科技有限公司
- 供应商报价：¥1
- 标签：Synuclein-α, Nitrated Monoclonal Antibody、Synuclein-α, Nitrated Monoclonal Antibody价格、Synuclein-α, Nitrated Monoclonal Antibody厂家、、、上海信裕生物科技有限公司
产品库
| Description |  | Monoclonal antibody against nitrated α-synuclein and unmodified α-synuclein |
| Intended Use | | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
| Clone | | Syn514 |
| Form | | Ascites |
| Host | | Mouse |
| Species Reactivity | | Synuclein-α, Nitrated Monoclonal AntibodyHuman |
| IsoType | | IgG1 |
| [Ab] | | 3-5 mg/mL |
| Specificity | | Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class-A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre-synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson¡¯s disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson¡¯s disease, Alzheimer¡¯s disease and several other neurodegenerative illnesses. Oxidative injury has been implicated in the pathogenesis of neurodegenerative disorders including Alzheimer¡¯s and Parkinson¡¯s disease. Syn514 was raised using oxidized alpha synuclein and recognizes native alpha synuclein and nitrated/oxidized alpha synuclein. Synuclein 514 also shows some cross reactivity with beta and gamma synucleins. |
| Uses | | Synuclein-α, Nitrated Monoclonal AntibodyThese antibodies are effective in immunoblotting and immunohistochemistry. It has been used effectively in paraffin embedded sections. |
| Suggested Working Dilution | | The optimal working dilution should be determined for each specific assay condition.
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| Storage | | Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. |
| References | | Duda J, Giasson B, Mabon M, Lee V, Trojanowski J. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol 52(2):205-210, 2002. Giasson B, Duda J, Murray I, Chen Q, Souza J, Hurtig H, Ischiropoulos H, Trojanowski J, Lee V. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290(5504):985-988, 2000. |
| Warranty/Conditions | | Covance products may not be resold or modified for resale without prior written approval. |
