Calponin (Basic) is an actin, tropomyosin and calmodulin binding protein thought to be involved in the regulation of smooth muscle contraction.
钙结合蛋白Calponin (Basic)抗体 Clone 26A11 7 mL BOND ready-to-use PA0416 P (HIER) Antigen Background Calponin (Basic) is an actin, tropomyosin ａnd calmodulin binding protein thought to be involved in the regulation of smooth muscle contraction. The expression of basic calponin is reported to be restricted to smooth muscle cells ａnd is a marker of the differentiated contractile phenotype of developing smooth muscle. Vascular smooth muscle cells convert to a synthetic dedifferentiated phenotype when this protein is lost ａnd this is a key stage in both atherosclerosis ａnd restenosis of coronary arteries after balloon angioplasty. It is thought that basic calponin exerts its effect via the cortical actin cytoskeleton ａnd therefore influences proliferation, the transformed phenotype ａnd the metastatic potential of tumor cells. Basic calponin mRNA is expressed in smooth muscle of prostate, bowel ａnd aorta whereas neutral and acidic calponin mRNAs are expressed in non-smooth muscle tissues such as heart, placenta, lung, kidney, pancreas, spleen, testis ａnd ovary as well as in smooth muscle-containing tissues. Breast carcinoma: immunohistochemical staining with BOND ready-to-use Calponin (Basic) (26A11) using BOND Polymer Refine Detection.
