Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and the epithelial membrane antigen (EMA).
徕卡抗体Anaplastic Lymphoma Kinase Clone 4 7 mL BOND ready-to-use PA0306 P (HIER) Antigen Background Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen ａnd the epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals ａnd may be associated with cutaneous ａnd extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23; q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25 percent of all non-Hodgkin＇s lymphomas in children ａnd young adults, of which one third carries the NPMALK gene translocation.
Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin section.
