Recombinant Human beta-NGF现货产品编号:
450-01
别名:
NGF-β, beta-Nerve Growth Factor
描述:
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 ａnd NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, ａnd plays a crucial role in the development ａnd preservation of the sensory ａnd sympathetic nervous systems. β-NGF also acts as a growth ａnd differentiation factor for B lymphocytes, ａnd enhances B-cell survival. The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids ａnd three disulfide bonds, which are required for biological activity.
氨基酸序列:
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.
交叉反应:
Chicken, Hamster, Mouse, Rat, Human, Leech
研究领域:
 | 血管生成/ 心血管 |  | 趋化 |
 | 糖尿病/ 体重调节 |  | 炎症 |
 | 神经生物学 |  | 干细胞及分化 |
 | 创伤修复 | |
原产国:
USA
