DAPK2 (N-term)，Rabbit Monoclonal IgG
- 产地：中国大陆
- 供应商：上海谱振生物有限公司
- 供应商报价：电议
- 标签：DAPK2 (N-term)，Rabbit Monoclonal IgG,智能控制,人机界面,供应DAPK2 (N-term)，Rabbit Monoclonal IgG,上海紫一试剂厂
产品库
| DAPK2 （N-term） Rabbit Monoclonal IgG |
| Cas 号： |
| 分子式： |
| 别 名： | DAP kinase 2, DAP-kinase-related protein 1, DRP-1 |
| 订货信息： |
| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 订购 |
| DAPK2 （N-term） | 100g | 询价 | 现货 | 订购 |
| 性 状： | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EP1633Y |
| 质量标准： | 【产品介绍】Protein kinase termed death-associated protein kinase 2 （DAPK2） dependant on calcium/ calmodulin （Ca2+/CaM） contains an N-terminal protein kinase domain followed by a conserved CaM-binding domain with significant homologies to those of DAP kinase, a protein kinase involved in apoptosis. Overexpression of DAPK2 significantly induced the m o r phological changes characteristic of apoptosis. Results indicate that DAPK2 is an additional member of DAP kinase family involved in apoptotic signaling （1）. The region of homology spans the catalytic domain a n d the CaM-regulat o r y region, whereas the remaining C-terminal part of the protein differs completely from DAP kinase a n d displays no homology to any known protein. The catalytic domain is also homologous to the recently identified ZIP kinase a n d to a lesser extent to the catalytic domains of DRAK1 a n d -2 （2）. DAPK2 has a novel regulat o r y mechanism that controls its pro-apoptotic functions. It comprises a single autophosph o r ylation event mapped to Ser308 within the CaM regulat o r y domain. A negative charge at this site reduces both the binding to CaM a n d the f o r mation of DRP-1 homodimers （3）.
DAPK2 （N-term），Rabbit Monoclonal IgG
DAPK2 （N-term），Rabbit Monoclonal IgG B. Immunohistochemical staining of paraffin-embedded |
