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Anti-Bile salt-activated lipase antibody，胆盐激活脂肪酶抗体

产品信息
Anti-Bile salt-activated lipase antibody，胆盐激活脂肪酶抗体，应用于IHC、WB、 IF、IP、ELISA等实验，公司生产的抗体每个流程都执行严格的检测标准，保证蛋白抗原产品质量，质量稳定，实验效果明显。按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。公司产品经无数次市场验证，若出
 产品编号Rs-5042R
英文名称Bile salt-activated lipase
中文名称胆盐激活脂肪酶抗体
别    名BAL; Bile salt-stimulated lipase; BSDL; BSSL; Bucelipase; Carboxyl ester lipase (bile salt stimulated lipase); Carboxyl ester lipase; CEase; CEL; CELL; Cholesterol esterase; FAP; FAPP; Fetoacinar pancreatic protein; LIPA; Lysophospholipase, pancreatic; MODY8. Pancreatic lysophospholipase; Sterol esterase antibody; CEL_HUMAN.   
说 明 书0.2ml  
研究领域肿瘤  细胞生物  免疫学  转录调节因子  转运蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
细胞定位分泌型蛋白 
性    状Lyophilized or Liquid
浓    度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Bile salt-activated lipase (151-180aa)
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract ａnd from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol ａnd lipid-soluble vitamin ester hydrolysis ａnd absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol ａnd oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment ａnd is probably not secreted. This gene contains a variable number of tandem repeat(VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq].


Function:
Catalyzes fat ａnd vitamin absorption. Acts in concert with pancreatic lipase ａnd colipase for the complete digestion of dietary triglycerides.


Subcellular Location:
Secreted.


Tissue Specificity:
Mammary gland ａnd pancreas.


DISEASE:
Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8) [MIM:609812]; also known as diabetes ａnd pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion ａnd frequent insulin-independence at the beginning of the disease.


Similarity:
Belongs to the type-B carboxylesterase/lipase family.


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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