脑肠肽(一种新的生长激素释放肽)多肽抗原 多肽

Overview

• Product nameGhrelin peptideSee all Ghrelin products （ 3 ） ...
• Protein descriptionSynthetic peptide （Human） Ghrelin, containing 28 amino acids ａnd a total molecular mass of 3371 Daltons. Swiss-Prot Q9UBU3

  Properties

• Purity> 95 % by SDS-PAGE
• Purification notesThis peptide was purified by proprietary chromatographic techniques. Purity: Greater than 98.0% as determined by: （a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
• FormLyophilised:Add deionized water to a working concentration approximately 0.5 mg/ml ａnd let the lyophilized pellet dissolve completely.
• Storage instructionsShipped at 4°C. Upon delivery aliquot ａnd store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  No additives
  
• Concentration Reconstitution Dependent
  
  Concentration information loading...
• Sequence notesGly-Ser-Ser（n-octanoyl）-Phe-Leu-Ser-Pro- Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu- Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro- Arg
• Research Areas
  • Metabolism
  • Types of disease
  • Obesity

  • Metabolism
  • Types of disease
  • Diabetes

  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Types of disease
  • Cancer

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cardiovascular
  • Blood
  • Other

  • Cardiovascular
  • Atherosclerosis
  • Diabetes associated

  • Neuroscience
  • Neurology process
  • Metabolism

Applications

Protein info

• Alternative names
  Appetite regulating hormoneGhrelinGhrelin 27

  Ghrelin 28Ghrelin/obestatin prepropeptideGHRLGHRL_HUMANGrowth hormone releasing peptideGrowth hormone secretagogueGrowth hormone-releasing peptideM46 proteinMotilin related peptideMotilin-related peptideMTLRPObestatinObestatin preprohormoneProtein M46

  see all

• FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 （GHSR）. Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity ａnd stimulates gastric acid secretion. Involved in growth regulation.
  Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity ａnd jejunal motility.
• Tissue specificityHighest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
• Sequence similaritiesBelongs to the motilin family.
• Post-translational
  modificationsO-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 ａnd Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
  Amidation of Leu-98 is essential for obestatin activity.