本公司经销Insulin/Proinsulin，胰岛素抗体，克隆类型为polyclonal，宿主来源是Rabbit，Insulin/Proinsulin胰岛素抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-0056R
英文名称：Anti-Insulin/Proinsulin
中文名称：胰岛素抗体
其他名称：名ILPR; INS; Insulin A chain; Insulin B chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 5.8/12kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Insulin is a pancreatic hormone that regulates glucose ａnd is involved in the synthesis of protein ａnd fat. It increases cell permeability to monosaccharides, amino acids ａnd fatty acids. It accelerates glycolysis, the pentose phosphate cycle, ａnd glycogen synthesis in liver. Heterodimer of a B chain ａnd an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I ａnd IGF-II （also desinated somatomedin C ａnd multiplication stimulating activator, respectvely）, share approximatly 76% sequence identity ａnd are 50% related to pro-insulin.IGF-I ａnd IGF-II are nonglycosylated, single chain proteins of 70 ａnd 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined. Function : Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids ａnd fatty acids. It accelerates glycolysis, the pentose phosphate cycle, ａnd glycogen synthesis in liver.Subunit : Heterodimer of a B chain ａnd an A chain linked by two disulfide bonds.Subcellular Location : Secreted.DISEASE : Defects in INS are the cause of familial hyperproinsulinemia （FHPRI） [MIM:176730]. Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 （IDDM2） [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia ａnd polyuria which result from hyperglycemia-induced osmotic dieresis ａnd secondary thirst. These derangements result in long-term complications that Defects in INS are a cause of diabetes mellitus permanent neonatal （PNDM） [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.Similarity : Belongs to the insulin family. 胰岛素（Isulin）胰岛素抗体是胰岛细胞分泌得一种激素，可以减底血糖浓度。此抗体和人胰岛素反应，并与大多数哺乳类动物的胰岛素有交叉反应，主要用于胰岛细胞瘤的功能性研究。 产品图片Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Insulin Polyclonal Antibody, Unconjugated（bs-0056R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: rat pancreas tissue;4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Insulin Polyclonal Antibody, Unconjugated（bs-0056R） 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, FITC conjugated（bs-0295G-FITC）used at 1:200 dilution for 40 minutes at 37°C.
