Anti-NG2/CSPG4黑色素瘤硫酸软骨素蛋白多糖4抗体
- 型号：BY-11192R
- 产地：其它
- 供应商：上海科敏生物科技有限公司
- 供应商报价：电议
- 标签：Anti-NG2/CSPG4黑色素瘤硫酸软骨素蛋白多糖4抗体,生物试剂,生物制剂,供应Anti-NG2/CSPG4黑色素瘤硫酸软骨素蛋白多糖4抗体,上海科敏生物科技有限公司
产品信息
本公司经销NG2/CSPG4，黑色素瘤硫酸软骨素蛋白多糖4抗体，克隆类型为polyclonal，宿主来源是Rabbit，NG2/CSPG4黑色素瘤硫酸软骨素蛋白多糖4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
本公司经销NG2/CSPG4，黑色素瘤硫酸软骨素蛋白多糖4抗体，克隆类型为polyclonal，宿主来源是Rabbit，NG2/CSPG4黑色素瘤硫酸软骨素蛋白多糖4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-11192R
英文名称：Anti-NG2/CSPG4
中文名称：黑色素瘤硫酸软骨素蛋白多糖4抗体
其他名称：名MELCSPG;AN2;AN2 proteoglycan;Chondroitin sulfate proteoglycan 4 （melanoma-associated）;Chondroitin sulfate proteoglycan 4;Chondroitin sulfate proteoglycan NG2;CSPG4;Cspg4 chondroitin sulfate proteoglycan 4;CSPG4_HUMAN;HMW-MAA;HSN tumor-specific antigen;Kiaa4232;MCSP;MCSPG;MEL-CSPG;Melanoma chondroitin sulfate proteoglycan;Melanoma-associated chondroitin sulfate proteoglycan;4732461B14Rik;MSK16.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 251kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：NG2 （also known as melanoma-associated chondroitin sulfate proteoglycan 4, MCSP, MCSPG, MSK16 ａnd MEL-CSPG） stabilizes cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. NG2 may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor invasion ａnd growth. Threonine 2256 phosphorylation of rat NG2 （Threonine 2252 phosphorylation of human NG2） leads to redistribution of NG2 on the surface of astrocytomas, polarization of the cell ａnd a significant increase in cell motility. NG2 acts as a co-receptor for spreading ａnd focal contact formation in association with Alpha 4 Beta1 integrin in malignant melanoma cells. NG2 is present on blood vessels throughout the rat embryo. Microvessels within the rat CNS express NG2 on endothelial cells, ａnd outside the CNS, NG2 is present on smooth muscle cells. NG2 is a novel marker for epidermal stem cells that contributes to their patterned distribution by promoting stem cell clustering.Function : Detected only in malignant melanoma cells.Subcellular Location : Apical cell membrane. Cell projection > lamellipodium membrane. Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes.
