Anti-Nicastrin老年性痴呆蛋白APH2抗体

本公司经销Nicastrin，老年性痴呆蛋白APH2抗体，克隆类型为polyclonal，宿主来源是Rabbit，Nicastrin老年性痴呆蛋白APH2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6058R
英文名称：Anti-Nicastrin
中文名称：老年性痴呆蛋白APH2抗体
其他名称：名Anterior pharynx defective 2; APH 2; APH2; NCSTN; NCT; NICA_HUMAN; Nicastrin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 75kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, cow, chk
产品介绍：The Presenilin 1 （PS1） ａnd Presenilin 2 （PS2） transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the ∫-Amyloid precursor protein （∫APP） ａnd Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of ∫APP ａnd results in the overproduction of the neurotoxic ∫-Amyloid peptide, which results in a condition associated with Familial Alzheimer’s disease （FAD）. A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of ∫APP, which makes nicastrin an attractive potential target for modulating the production of ∫-Amyloid in patients with Alzheimer’s disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino ａnd carboxy-terminal domains, a short, hydrophobic transmembrane domain ａnd potential N-myristoylation ａnd phosphorylation sites.Function : Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors ａnd APP （beta-amyloid precursor protein）. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.Subunit : Belongs to the nicastrin family.Subcellular Location : Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.Tissue Specificity : Widely expressed.DISEASE : Defects in NCSTN are the cause of familial acne inversa type 1 （ACNINV1） [MIM:142690]. A chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, ａnd disfiguring scars. Manifestations typically appear after puberty.Similarity : Belongs to the nicastrin family.