本公司经销Perlecan/Heparan Sulfate Proteoglycan 2，硫酸乙酰肝素蛋白多糖2，克隆类型为polyclonal，宿主来源是Rabbit，Perlecan/Heparan Sulfate Proteoglycan 2硫酸乙酰肝素蛋白多糖2可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-5072R
英文名称：Anti-Perlecan/Heparan Sulfate Proteoglycan 2
中文名称：硫酸乙酰肝素蛋白多糖2
其他名称：名Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin （domain V region）; Heparan Sulfate Proteoglycan; Heparan sulfate proteoglycan of basement membrane; HSPG 2; HSPG; Hspg2; LG3 peptide; Perlecan; PLC antibody Schwartz Jampel syndrome 1 （chondrodystrophic myotonia）; SJA antibody SJS antibody SJS1 antibody.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 469kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, cow
产品介绍：This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans（heparan sulfate or chondroitin sulfate） are attached. The perlecan protein is a large multidomain proteoglycan that binds to ａnd cross-links many extracellular matrix components ａnd cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 ａnd Transthyretin, etc. ａnd plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation ａnd is thus thought to help maintain vascular homeostasis. It can also promote growth factor （e.g., FGF2） activity ａnd thus stimulate endothelial growth ａnd re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules ａnd cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, ａnd Tardive dyskinesia.[provided by RefSeq, Mar 2010].Subcellular Location : Secreted, extracellular space, extracellular matrix, basement membrane.Tissue Specificity : Found in the basement membranes.Similarity : Contains 4 EGF-like domains. Contains 22 Ig-like C2-type （immunoglobulin-like） domains. Contains 11 laminin EGF-like domains. Contains 3 laminin G-like domains. Contains 3 laminin IV type A domains. Contains 4 LDL-receptor class A domains. Contains 1 SEA domain.[FUNCTION] Integral component of basement membranes. Component of the glomerular basement membrane （GBM）, responsible for the fixed negative electrostatic membrane charge, ａnd which provides a barrier which is both size- ａnd charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development ａnd for regulating the vascular response to injury. Also required for avascular cartilage development.[FUNCTION] Endorepellin in an anti-angiogenic ａnd anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis ａnd blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin ａnd type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.[FUNCTION] The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.产品图片Antigen: bs-5072P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
