本公司经销MMS19，DNA修复甲基磺酸敏感性基因19抗体，克隆类型为polyclonal，宿主来源是Rabbit，MMS19DNA修复甲基磺酸敏感性基因19抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-8671R
英文名称：Anti-MMS19
中文名称：DNA修复甲基磺酸敏感性基因19抗体
其他名称：名MET18MMS19 nucleotide excision repair homolog; methyl methanesulfonate sensitivity gene19; MMS19L; MMS-19L; MMS 19 nucleotide excision repair homolog MET18.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 113kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, dog, Rb
产品介绍：MMS19 is a 1,030 amino acid nuclear protein containing seven HEAT repeats that belongs to the MET18/MMS19 family. Via its interactions with TFIIH p80 ａnd TFIIH p89 helicases, MMS19 plays a role in nucleotide excision repair （NER） ａnd RNA polymerase II （Pol II） transcription. MMS19 may also function as a transcriptional coactivator of estrogen receptor. While ubiquitously expressed, highest levels of MMS19 have been found in testis. At least five distinct MMS19 protein isoforms exist, which are produced by alternative splicing events. The gene encoding MMS19 maps to human chromosome 10q24.1, ａnd is associated with the risk of pancreatic cancer.Function : MMS19 like protein may play a role in nucleotide excision repair （NER） ａnd RNA polymerase II （POL II） transcription by interacting with ERCC2/XPD ａnd ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. It may also function as a transcriptional coactivator of estrogen receptor （ER） ａnd may be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters ａnd cell types. It is ubiquitously expressed with higher expression in testis.Subunit : Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 ａnd SLC25. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB ａnd NCOA3/RAC3.Subcellular Location : Nuclear.Tissue Specificity : Ubiquitously expressed with higher expression in testis.Similarity : Belongs to the MET18/MMS19 family.Contains 7 HEAT repeats.
