RAD51C乳腺癌和卵巢癌易感基因RAD51C抗体

本公司经销RAD51C，乳腺癌和卵巢癌易感基因RAD51C抗体，克隆类型为polyclonal，宿主来源是Rabbit，RAD51C乳腺癌和卵巢癌易感基因RAD51C抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2186R
英文名称：Anti-RAD51C
中文名称：乳腺癌和卵巢癌易感基因RAD51C抗体
其他名称：名tudor domain containing 1; Tdrd1; MTR-1; FLJ21082; CT41.1; TDRD1_HUMAN.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 132kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, hrs, pig
产品介绍：Essential for the homologous recombination （HR） pathway of DNA repair. Involved in the homologous recombination repair （HRR） pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA ａnd specifically to nicks in duplex DNA. Participates in branch migration ａnd Holliday junction resolution ａnd thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 ａnd thereby transduction of the damage signal, leading to cell cycle arrest ａnd HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 ａnd XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion ａnd genomic stability. Involved in maintaining centrosome number in mitosis.Function : Plays a central role during spermatogenesis by participating in the repression transposable elements ａnd prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs ａnd Piwi proteins ａnd govern the methylation ａnd subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool ａnd limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts ａnd piRNAs into Piwi proteinsSubunit : Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 ａnd DDX4. Interacts with MAEL. Interacts with PIWIL1, PIWIL2 ａnd PIWIL4 （when methylated on arginine residues） Subcellular Location : Cytoplasm （By similarity）. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis （By similarity）. Also present in chromatoid bodyTissue Specificity : Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen ａnd prostate.Similarity : Belongs to the TDRD1 family. Contains 1 MYND-type zinc finger. Contains 4 Tudor domains.