PDC6I/Alix调亡诱导因子6相互作用蛋白/多巴胺受体相互作用蛋白4抗体

本公司经销PDC6I/Alix，调亡诱导因子6相互作用蛋白/多巴胺受体相互作用蛋白4抗体，克隆类型为polyclonal，宿主来源是Rabbit，PDC6I/Alix调亡诱导因子6相互作用蛋白/多巴胺受体相互作用蛋白4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6767R
英文名称：Anti-PDC6I/Alix
中文名称：调亡诱导因子6相互作用蛋白/多巴胺受体相互作用蛋白4抗体
其他名称：名AIP1; ALG 2 interacting protein 1; ALG-2-interacting protein 1; ALG2 interacting protein X; Alix; Apoptosis linked gene 2 interacting protein X; Dopamine receptor interacting protein 4; DRIP4; HP95; KIAA1375; MGC17003; PDC6I_HUMAN; PDCD6 interacting protein; PDCD6-interacting protein; PDCD6IP; Programmed cell death 6 interacting protein; Programmed cell death 6-interacting protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 95 kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Class E VPS protein involved in concentration ａnd sorting of cargo proteins of the multivesicular body （MVB） for incorporation into intralumenal vesicles （ILVs） that are generated by invagination ａnd scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid （LBPA） which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II ａnd -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis ａnd enveloped virus budding （HIV-1 ａnd other lentiviruses）. Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis ａnd cell proliferation.Function : Class E VPS protein involved in concentration ａnd sorting of cargo proteins of the multivesicular body （MVB） for incorporation into intralumenal vesicles （ILVs） that are generated by invagination ａnd scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid （LBPA） which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II ａnd -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis ａnd enveloped virus budding （HIV-1 ａnd other lentiviruses）. Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis ａnd cell proliferation.Subunit : Interacts with SH3KBP1. Interacts with PDCD6 ａnd TSG101 in a calcium-dependent manner. Interacts with ａnd SGSM3. Self-associates. Interacts with CHMP4A; the interaction is direct. Interacts with CHMP4B; the interaction is direct. Interacts with CHMP4C; the interaction is direct. Interacts with HIV-1 p6. Interacts with EIAV p9; the interaction has been shown in vitro. Interacts with CEP55; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry. May interact with PDGFRB. Interacts with SH3GL1 ａnd SH3GL2. Interacts with murine leukemia virus Gag polyprotein （via LYPX（n）L motif）. Interacts with murine leukemia virus Gag polyprotein （via LYPX（n）L motif）.Subcellular Location : Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells.Post-translational modifications : May be phosphorylated on tyrosine residues by activated PDGFRB.Similarity : Contains 1 BRO1 domain.