本公司经销NIPP1/ARD1，核YZ蛋白磷酸酶1抗体，克隆类型为polyclonal，宿主来源是Rabbit，NIPP1/ARD1核YZ蛋白磷酸酶1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-3658R
英文名称：Anti-NIPP1/ARD1
中文名称：核YZ蛋白磷酸酶1抗体
其他名称：名Activator of RNA decay; ARD 1; ARD1; Homolog of E.coli RNase E; NIPP 1; NIPP1; Nuclear inhibitor of protein phosphatase 1; Nuclear subunit of PP1; PPP1R8; Protein phosphatase 1 regulatory inhibitor subunit 8; Protein phosphatase 1 regulatory subunit 8; RNase E.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb, hrs, cow, chk, Gpig, Danio rerio
产品介绍：Inhibitor subunit of the major nuclear protein phosphatase 1 （PP1）. It has RNA binding activity but does not cleave RNA ａnd may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA ａnd might act as a transcriptional repressor. Seems to be required for cell proliferation.Function : Inhibitor subunit of the major nuclear protein phosphatase-1 （PP-1）. It has RNA-binding activity but does not cleave RNA ａnd may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA ａnd might act as a transcriptional repressor. Seems to be required for cell proliferation.Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3＇ to purines ａnd pyrimidines in A+U-rich regions. It generates 5＇-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.Subunit : Interacts with phosphorylated CDC5L, SF3B1 ａnd MELK. Interacts with EED, in a nucleic acid-stimulated manner. Part of a complex consisting of PPP1R8, EED, HDAC2 ａnd PP-1. Part of the spliceosome. Interacts with PPP1CA, PPP1CB ａnd PPP1CC.Subcellular Location : Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear. Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.Tissue Specificity : Ubiquitously expressed, with highest levels in heart ａnd skeletal muscle, followed by brain, placenta, lung, liver ａnd pancreas. Less abundant in kidney. The concentration ａnd ratio between isoforms is cell-type dependent. Isoform Alpha （>90%） ａnd isoform Beta were found in brain, heart ａnd kidney. Isoform Gamma is mainly found in B-cells ａnd T-lymphocytes, ａnd has been found in 293 embryonic kidney cells.Post-translational modifications : May be inactivated by phosphorylation on Ser-199 or Ser-204. Phosphorylated by Lyn in vitro on Tyr-264, ａnd also on Tyr-335 in the presence of RNA.Similarity : Contains 1 FHA domain.NIPP1是一种普遍存在于细胞核中的蛋白，它在剪接体的装配中发挥着重要作用，主要体现在细胞的分化，增值及迁移中。经研究，目前NIPP1在乳腺肿瘤、前列腺癌,以及肺癌中有较高频率的表达,其中乳腺肿瘤中的表达频率,达到70%,远高于其他肿瘤组织。表明ARD1蛋白的高表达可能是乳腺肿瘤组织的一个标志。
